Living Nonkilling
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Each reader is first asked to reflect upon the question: "Is a non killing society possible?" If not, why not? If yes, why?l For the purpose of the question, a non killing society is taken to be a human commu nity from smallest to largest encompassing all humankind that has the following characteristics: There is no killing of humans, at least, and no threats to kill. There are no weapons for ...
متن کاملTransience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42.
Cytolytic effectors polarize toward target cells for effective killing and IFN-gamma secretion. The spatiotemporal features of this polarization and their importance for cytolysis have not been resolved. In cytotoxic T cells and natural killer (NK) cells, transient polarization was consistently associated with effective killing. Polarization was regulated by Cdc42, a small Rho family GTPase uni...
متن کاملEscherichia coli DNA topoisomerase I copurifies with Tn5 transposase, and Tn5 transposase inhibits topoisomerase I.
Tn5 transposase (Tnp) overproduction is lethal to Escherichia coli. Genetic evidence suggested that this killing involves titration of E. coli topoisomerase I (Topo I). Here, we present biochemical evidence that supports this model. Tn5 Tnp copurifies with Topo I while nonkilling derivatives of Tnp, Delta37Tnp and Delta55Tnp (Inhibitor [Inh]), show reduced affinity or no affinity, respectively,...
متن کاملChromosomal and nonchromosomal mutations affecting the "killer character" of Saccharomyces cerevisiae.
The "killer character" of Saccharomyces cerevisiae is a nonchromosomal genetic element which imparts to cells carrying it (a) the ability to kill cells which lack it, by secreting the soluble macromolecular killer substance and (b) the ability to resist the killing effects of the killer substance.-Mutants have been isolated from S. cerevisiae carrying the "killer character". Mutants were found ...
متن کاملEffects of neutrophils on cefazolin activity and penicillin-binding proteins in Staphylococcus aureus abscesses.
Bacteria survive within abscesses despite antimicrobial therapy, usually necessitating drainage. Our previous work showed that bacterial killing is diminished within the neutrophils of animals with abscesses. To further assess the role of neutrophils in Staphylococcus aureus survival and the poor activities of beta-lactams in abscesses, tissue cage abscess-bearing rats were given polymorphonucl...
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تاریخ انتشار 2012